Les is musing on the idea of a revolver chambered for an autopistol caliber. While he seems to be settling on the .45ACP-caliber Model 625, he also pondered the possibilities of one chambered in .40 S&W or 10mm Auto.
Above is the S&W Model 646, one of a limited run of 900 .40-caliber revolvers done in 2003 to use up their remaining stock of no-lock frames. It's a 4" round-butt L-frame with a 6-shot titanium cylinder. The titanium is required to squeeze six .40-cal holes into an L-frame's cylinder: it's slightly more elastic than steel, and therefore less likely to fracture at the thin spots. I replaced the rubber Hogue Bantam grip that came on the gun with a Monogrip in Pau Ferro, and the gun handles and points like... well, like a round-butt 4" medium-frame Smith usually does: Superbly.
Obviously the only way to find one would be to scare one up used, but if Les goes with the .45 ACP 625, I don't think he'll be disappointed.
(That's a 625-4 next to the Kimber Custom Classic Stainless LE...)