Now, there have been US and Coalition boots on the ground in Mesopotamia before, but at that time, the civilized world wasn't forcing a showdown with the possibly-nuclear-armed country next door. And the last time the civilized world was worried about Iran, there weren't international troops putting the smackdown on Mujahedeen guerillas in Afghanistan. And the last time foreign troops were fighting Islamic guerillas in Afghanistan, said guerillas weren't blowing up civilians in India. (Who has nukes, and hasn't any love lost for Pakistan, which has always been Muj Central.)
So, what we have here is a rising storm of conflict, brewing along an arc running from the mouths of the Indus to the Nile Delta. Civilization's home turf, as it were, is sporting very few signs of it these days. That may be the soil where writing and agriculture and beer and other good things first sprang from, but that's not all that was invented there, and sometimes it shows.
It looks like we're in for some interesting times.