.22LR pocket pistols have largely been the realm of "Ring of Fire" zinc blowback guns, at least as far as domestic manufacturers have been concerned. Italian manufacturer Beretta has built its Model 21A Bobcat at its Maryland facility, due to GCA '68 import points restrictions, and the Brazilian firm Taurus makes its little tip-up Bobcat clone stateside for the same reasons.
For a brief time in the Seventies, Smith & Wesson sold the tiny five-shot (5+1 for the adventuresome) Model 61 Escort, and now Ruger is offering their LCP II in a ten-shot .22LR variant.
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