Saw some creepy-looking pictures of a S&W Model 329 Night Guard that suffered a catastrophic frame failure.
Note that this had bupkis to do with the ammunition being improperly loaded: This was not a "ka-BOOM". The cylinder and barrel are quite intact.
This was apparently with Remington's 180gr load, which is to the .44 what the high-velocity 125gr loads are to the .357 Magnum. It is a very high velocity projectile, in excess of 1600fps at the muzzle, which means it's probably hitting the forcing cone at over 1,000fps.
If I had to pull a guess out of a hat, the barrel was improperly torqued, putting the frame under stress, and it just fractured under the pounding. The failure mode is almost identical to the one suffered by Will's S&W PC625 (another alloy N-frame, which gave up the ghost firing comparatively tame 185gr .45ACP.)
Both my daily carry revolvers are alloy-framed guns with the two-piece barrel, and to give Smith their due, the failure rate is awfully low for the volume they sell, but this is bad PR.