So, I posit that there is a subatomic particle called the "annoyon".
There's a general background of these annoyons sleeting through the universe, and occasionally they strike people. Depending on how energetic they are, an annoyon will decay in anywhere from a matter of seconds to a few minutes.
The problems in life arise when a person is bombarded by a stream of annoyons such that an annoyance charge builds up faster than the particles can decay.
I further posit that certain things emit annoyons. Heated platinum, for example, which is found in automobile catalytic converters. This would explain why heavy traffic is like taking a bath in annoyance while attending an auto race, where the cars have no catalytic converters, is merely an excuse to relax and drink beer.
I would assume that electron guns, such as those found in CRT monitors, beam a steady stream of annoyons mingled with the electrons, which would explain why watching network TV or reading the internet is an exercise in face-palming, hair-pulling aggravation, but this doesn't explain why doing these activities is so irksome even when done on an electron-gun-free LCD display.
Obviously I'm still working on this. I need millions in grant leech cash.